Can Targeting NADPH Metabolism Be a Therapeutic Strategy?
Given NADPH's critical role in cancer cell survival and proliferation, targeting NADPH metabolism presents an attractive therapeutic strategy. Several approaches are being explored, including inhibiting key enzymes in the NADPH production pathways such as glucose-6-phosphate dehydrogenase (G6PD) and isocitrate dehydrogenase (IDH). Additionally, disrupting NADPH-dependent antioxidant systems could selectively induce oxidative stress in cancer cells, leading to their death while sparing normal cells.
