What Are the Challenges in Targeting NADPH in Cancer Therapy?
While targeting NADPH metabolism holds promise, several challenges exist. One major challenge is the potential toxicity to normal cells, as NADPH is also essential for normal cellular functions. Achieving specificity in targeting cancer cells without affecting healthy tissues is critical. Additionally, cancer cells may develop resistance to NADPH-targeted therapies through compensatory metabolic pathways, necessitating combination strategies to enhance therapeutic efficacy. Understanding the complex regulatory networks involving NADPH in cancer cells is essential for developing effective therapies.
