Are There Any Emerging Therapies Targeting Aerobic Glycolysis?
Yes, several emerging therapies aim to disrupt glycolysis in cancer cells. Inhibitors of glycolytic enzymes like hexokinase, phosphofructokinase, and pyruvate kinase M2 are being explored. Additionally, strategies that target regulatory pathways, such as the HIF-1α and mTOR pathways, are under investigation. Combining glycolytic inhibitors with traditional therapies may enhance treatment efficacy and overcome resistance.