Can targeting the cytoskeleton prevent metastasis?
Targeting the cytoskeleton holds potential in preventing metastasis, a major cause of cancer-related mortality. Inhibitors of actin polymerization, such as cytochalasins, have shown promise in reducing cancer cell motility and invasion in preclinical studies. Additionally, targeting regulatory proteins like Rho GTPases and MAPs could disrupt the cytoskeletal dynamics necessary for metastasis. However, the challenge lies in achieving specificity to avoid affecting normal cellular functions, as the cytoskeleton is also essential for normal cell physiology.
