How do cytoskeletal dynamics influence cancer therapeutics?
Cytoskeletal dynamics have significant implications for cancer therapeutics. Many anticancer drugs target the cytoskeleton to inhibit cancer cell proliferation and induce cell death. For instance, taxanes and vinca alkaloids disrupt microtubule dynamics, preventing mitotic spindle formation and inducing apoptosis. However, cancer cells can develop resistance to these drugs by altering cytoskeletal components or upregulating drug efflux pumps. Understanding cytoskeletal dynamics can lead to the development of new therapeutic strategies that overcome resistance and target metastatic pathways more effectively.
