Breast cancer can also be a source of chest pain, especially if the cancer has metastasized to the chest wall, ribs, or spine. Pain may be felt in the chest, back, or shoulders. Furthermore, treatments for breast cancer, such as surgery (mastectomy), radiation therapy, or chemotherapy, can cause pain in the chest area. Post-mastectomy pain syndrome (PMPS) is one example where patients experience chronic pain, numbness, or tingling in the chest, armpit, or arm following surgery.