APBs can be detected using a combination of techniques such as [immunofluorescence](#) and [fluorescence in situ hybridization (FISH)](#). Immunofluorescence allows for the visualization of PML protein, while FISH targets telomeric DNA sequences. Co-localization of these signals indicates the presence of APBs. Advanced microscopy techniques like super-resolution microscopy further enhance the detection and characterization of these structures.
