ALT Associated PML Bodies (APBs) are nuclear structures found in a subset of cancer cells that utilize the Alternative Lengthening of Telomeres (ALT) pathway for telomere maintenance. Unlike most cancer cells that rely on telomerase, ALT-positive cells maintain their telomeres through recombination-based mechanisms. APBs are characterized by the presence of telomeric DNA, telomere-binding proteins, and [PML protein](#) within [promyelocytic leukemia (PML)](#) nuclear bodies.
