How are DNA Crosslinks Utilized in Cancer Therapy?
Despite their potential to cause damage, DNA crosslinks are exploited in cancer therapy. Agents like cisplatin, carboplatin, and oxaliplatin are widely used in chemotherapy to induce DNA crosslinks, thereby triggering cell death in rapidly dividing cancer cells. The efficacy of these agents relies on their ability to overwhelm the cancer cells' repair mechanisms, leading to apoptosis.
