Diagnosis typically involves a combination of imaging techniques such as CT scans, MRI, and endoscopic ultrasound (EUS). These imaging methods help in assessing the cyst's characteristics, such as size, location, and the presence of solid components, which are critical for determining the likelihood of malignancy. Fine-needle aspiration (FNA) can be used to extract cyst fluid for cytological examination and biochemical analysis, including measuring levels of carcinoembryonic antigen (CEA) and amylase.