What Challenges Exist in Targeting Overexpression?
One of the challenges in targeting overexpression is the specificity of therapies. Many proteins that are overexpressed in cancer are also present in normal cells, albeit at lower levels. This can lead to off-target effects and toxicity. Another challenge is the development of resistance, where cancer cells may find ways to bypass the inhibited pathways. Combination therapies and novel delivery mechanisms are being explored to overcome these challenges.
