Diagnosing receptor abnormalities in cancer typically involves a combination of molecular and histopathological techniques. Immunohistochemistry (IHC) is widely used to detect receptor protein expression in tissue samples. Molecular techniques like PCR and next-generation sequencing (NGS) can identify genetic mutations or amplifications in receptor genes. Additionally, fluorescence in situ hybridization (FISH) can be used to detect gene amplifications or translocations.
