Cells have evolved intricate DNA repair mechanisms to address SSBs. The primary pathway for repairing SSBs is the base excision repair (BER) pathway. This process involves several steps: recognition of the damage, excision of the damaged base, end processing, gap filling, and ligation. Proteins such as PARP (Poly ADP-Ribose Polymerase) play a crucial role in detecting and signaling SSBs, recruiting other repair proteins to the site of damage.
