How Can Alternative Splicing Be Targeted for Cancer Therapy?
Targeting alternative splicing offers a novel approach for cancer therapy. One strategy involves the use of splice-switching oligonucleotides (SSOs) that can modulate splicing patterns to produce more favorable isoforms. Another approach is the development of small molecules that can inhibit specific splicing factors involved in cancer. For example, compounds that inhibit the splicing factor SRPK1 have shown promise in preclinical studies.
