What Are Some Examples of Aberrant Splicing in Cancer?
One prominent example is the Bcl-x gene, which can be spliced into two isoforms: Bcl-xL, an anti-apoptotic protein, and Bcl-xS, a pro-apoptotic protein. In many cancers, the balance shifts towards the Bcl-xL isoform, promoting cell survival. Another example is the splicing of the CD44 gene, which produces various isoforms associated with cell adhesion, migration, and metastasis.
