centromere

How Can Centromere Dysfunction Be Targeted in Cancer Therapy?

Targeting centromere dysfunction offers a novel approach for cancer therapy:
1. Aurora Kinase Inhibitors: These drugs inhibit Aurora Kinase B, disrupting chromosome segregation and inducing apoptosis in cancer cells. Several Aurora kinase inhibitors are currently in clinical trials.
2. Histone Modifiers: Modifying the histone proteins at the centromere can affect chromosomal stability. Drugs targeting histone acetylation or methylation at centromeres are being explored for their anti-cancer potential.
3. Survivin Inhibitors: As survivin is overexpressed in many cancers, survivin inhibitors can induce apoptosis and increase the sensitivity of cancer cells to chemotherapy.

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