Centromere-related biomarkers are used to diagnose and monitor cancer:
1. CENP-A: Overexpression of CENP-A, a histone protein variant specific to centromeres, is often observed in several types of cancer, including breast, colorectal, and prostate cancers. CENP-A levels can serve as a prognostic marker for these cancers.
2. Aurora Kinase B: This kinase is crucial for correct chromosome segregation. Elevated levels of Aurora Kinase B are seen in many cancers and are linked to poor clinical outcomes.
3. Survivin: This protein inhibits apoptosis and is involved in chromosome segregation during mitosis. High levels of survivin are often found in cancer cells and are associated with resistance to chemotherapy.
