What Are the Challenges in Studying the TCA Cycle in Cancer?
Studying the TCA cycle in cancer is challenging due to the dynamic and context-dependent nature of cancer metabolism. Tumor heterogeneity, the influence of the tumor microenvironment, and the interaction with immune cells add layers of complexity. Advanced techniques like stable isotope tracing, metabolomics, and single-cell analysis are being employed to unravel these complexities and provide a more comprehensive understanding of cancer metabolism.
