How Does the TCA Cycle Interact with Other Metabolic Pathways in Cancer?
The TCA cycle is intricately linked with other metabolic pathways, including glycolysis, the pentose phosphate pathway, and fatty acid oxidation. Cancer cells often exhibit a rewired metabolism to support rapid proliferation and survival under adverse conditions. For example, the increased flux through glycolysis provides intermediates for biosynthesis and NADPH for redox balance, while the TCA cycle intermediates support the synthesis of macromolecules required for cell growth.
