Several strategies are being explored to overcome drug resistance in cancer. One approach is the development of next-generation inhibitors that can target resistant cancer cells. Combination therapies that use multiple drugs to target different pathways simultaneously may also be effective in preventing or overcoming resistance. Another strategy involves targeting the tumor microenvironment to disrupt the protective niches that support resistant cells. Personalized medicine, which tailors treatment based on the genetic profile of the tumor, is another promising approach to address drug resistance.