What Are the Challenges in Targeting Tryptophan Metabolism?
Targeting tryptophan metabolism in cancer presents several challenges. One major obstacle is the redundancy and complexity of metabolic pathways, which may allow cancer cells to adapt and utilize alternative routes to sustain growth and evade the immune response. Additionally, the systemic effects of altering tryptophan metabolism need to be carefully considered to avoid unintended consequences on normal physiological processes.
