Are There Any Therapeutic Approaches Targeting Tryptophan Metabolism?
Yes, several therapeutic strategies are being explored to target tryptophan metabolism in cancer. IDO inhibitors and TDO inhibitors are being developed to block the conversion of tryptophan to kynurenine, thereby restoring immune function. Some of these inhibitors are currently being tested in clinical trials to evaluate their efficacy in combination with other treatments such as checkpoint inhibitors.
