Targeting cancer metabolism involves using inhibitors or drugs that disrupt specific metabolic pathways. For example:
Glycolysis Inhibitors: Compounds like 2-deoxy-D-glucose (2-DG) inhibit glycolysis, reducing energy production in cancer cells. Glutaminase Inhibitors: Drugs like CB-839 inhibit glutaminase, an enzyme critical for glutamine metabolism, hindering cancer cell growth. Fatty Acid Synthesis Inhibitors: Drugs such as TVB-2640 target fatty acid synthase, disrupting lipid synthesis essential for cancer cells. Pentose Phosphate Pathway Inhibitors: Inhibitors like 6-aminonicotinamide (6-AN) target enzymes in this pathway, affecting nucleotide synthesis and redox balance.
