What are the Challenges of Metabolic Interventions?
While promising, metabolic interventions face several challenges:
Tumor Heterogeneity: Different tumors and even cells within the same tumor may exhibit distinct metabolic profiles, complicating treatment. Drug Resistance: Cancer cells can adapt to metabolic inhibitors, developing resistance over time. Toxicity: Metabolic inhibitors can affect normal cells, leading to potential side effects and toxicity. Biomarker Identification: Identifying reliable biomarkers for patient selection and monitoring response to treatment is crucial but challenging.
