Several strategies have been explored to inhibit STAT3, including:
Small molecule inhibitors that block STAT3 phosphorylation and dimerization. Oligonucleotide-based approaches such as antisense oligonucleotides and siRNA that target STAT3 mRNA for degradation. Natural compounds like curcumin and resveratrol that have been shown to inhibit STAT3 activity. Peptide inhibitors that disrupt the interaction between STAT3 and its upstream activators or DNA.
