Researchers are exploring various strategies to inhibit MRP1 and overcome drug resistance:
MRP1 Inhibitors: Small molecules and antibodies that specifically inhibit MRP1 function are under investigation. RNA Interference: Techniques like siRNA and shRNA can be used to downregulate MRP1 expression in cancer cells. Combination Therapies: Using MRP1 inhibitors in conjunction with conventional chemotherapy agents may enhance drug accumulation and tumor cell death.
