What are the Mechanisms Behind MRP1-Mediated Drug Resistance?
MRP1 mediates drug resistance through several mechanisms:
ATP-Driven Efflux: MRP1 uses energy from ATP hydrolysis to transport drugs out of cells. Substrate Versatility: The protein can transport a wide range of substrates, including chemotherapeutic agents like doxorubicin, vincristine, and etoposide. Protection Against Oxidative Stress: By exporting glutathione conjugates, MRP1 helps in mitigating oxidative stress, which is often induced by chemotherapeutic agents.
