How Can the Tumor Immune Microenvironment Be Targeted?
Targeting the TIME involves strategies to modulate the immune response. Approaches include reprogramming TAMs from a pro-tumoral to an anti-tumoral phenotype, depleting Tregs to alleviate immune suppression, and enhancing the cytotoxic activities of natural killer cells. Combination therapies that simultaneously target multiple components of the TIME are being explored to improve therapeutic outcomes.
