Which Cells Are Involved in the Tumor Immune Microenvironment?
The TIME is composed of a diverse array of cells, including immune cells such as T-cells, B-cells, macrophages, dendritic cells, and natural killer cells. These immune components interact with non-immune cells like fibroblasts, endothelial cells, and the extracellular matrix. Tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) often create an immunosuppressive environment, facilitating tumor growth and evading immune surveillance.
