tumor microenvironment:

How Can the Tumor Microenvironment be Targeted for Therapy?

Targeting the TME presents a promising strategy for cancer therapy. Approaches include:
Immune Checkpoint Inhibitors: These drugs release the brakes on the immune system, allowing it to attack tumor cells more effectively.
Anti-Angiogenic Agents: These inhibit the formation of new blood vessels, starving the tumor of nutrients.
CAF Inhibitors: Targeting CAFs can disrupt the supportive stroma, slowing tumor growth.
ECM Modulators: These agents can alter the ECM to make it less conducive to tumor progression.

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