How Can the Tumor Microenvironment be Targeted for Therapy?
Targeting the TME presents a promising strategy for cancer therapy. Approaches include:
Immune Checkpoint Inhibitors: These drugs release the brakes on the immune system, allowing it to attack tumor cells more effectively. Anti-Angiogenic Agents: These inhibit the formation of new blood vessels, starving the tumor of nutrients. CAF Inhibitors: Targeting CAFs can disrupt the supportive stroma, slowing tumor growth. ECM Modulators: These agents can alter the ECM to make it less conducive to tumor progression.