What are the Key Cellular Components of the Tumor Microenvironment?
The TME comprises various cellular components, including:
Cancer-Associated Fibroblasts (CAFs): They secrete growth factors and remodel the extracellular matrix. Immune Cells: These include T cells, macrophages, and natural killer (NK) cells, which can either promote or inhibit tumor growth. Endothelial Cells: They form blood vessels that supply nutrients to the tumor. Extracellular Matrix (ECM): A network of proteins and polysaccharides that provide structural support.
