How do Alterations in Drug Metabolism Contribute to Resistance?
Alterations in drug metabolism can affect the efficacy of chemotherapy. Overexpression of drug efflux pumps, like P-glycoprotein, can lead to decreased intracellular concentrations of chemotherapeutic agents, rendering them less effective. Additionally, changes in enzymes involved in drug activation or detoxification, such as cytochrome P450 enzymes, can also contribute to resistance.
