What are the Genetic Mechanisms of Drug Resistance?
Genetic mechanisms of drug resistance involve changes in the DNA of cancer cells. Mutations in genes that encode drug targets can render therapies ineffective. For example, mutations in the EGFR gene can confer resistance to EGFR inhibitors in non-small cell lung cancer. Additionally, amplification of certain oncogenes, such as HER2 in breast cancer, can lead to resistance to targeted therapies like trastuzumab.
