How do amino acids affect the tumor microenvironment?
The tumor microenvironment (TME) is a complex milieu comprising cancer cells, stromal cells, immune cells, and extracellular matrix components. Amino acids can modulate the TME in various ways. For instance, tryptophan metabolism through the kynurenine pathway can suppress local immune responses, aiding in immune evasion by cancer cells. Additionally, amino acids like arginine can influence the function and infiltration of immune cells, such as T-cells and macrophages, within the TME.
