How do Antigen Loss Variants Impact Cancer Treatment?
The emergence of ALVs can significantly impact the effectiveness of cancer treatment. For example, therapies that target specific antigens, such as CAR-T cell therapy or monoclonal antibodies, may become less effective if the targeted antigens are lost or downregulated. Additionally, ALVs can contribute to tumor heterogeneity, making it more challenging to eradicate all cancer cells and increasing the likelihood of relapse.
