What Strategies Exist to Overcome Antigen Loss Variants?
Several strategies are being explored to overcome the challenge of ALVs in cancer treatment:
Developing multi-targeted therapies that target multiple antigens simultaneously to reduce the likelihood of resistance. Using immune checkpoint inhibitors to enhance the immune system's ability to recognize and attack cancer cells, including those with antigen loss. Adopting combination therapy approaches that pair antigen-targeted treatments with other modalities, such as chemotherapy or radiation. Investigating adaptive immune strategies that can respond to the dynamic changes in antigen expression on cancer cells.
