How do Aurora Kinases Contribute to Cancer Progression?
Aurora kinases contribute to cancer progression through several mechanisms:
- Chromosomal Instability: Overexpression of Aurora A can lead to centrosome amplification, resulting in uneven chromosome segregation and aneuploidy. - Cell Cycle Regulation: Aurora B is involved in the proper attachment of chromosomes to the mitotic spindle. Its dysregulation can cause improper chromosome alignment and segregation. - Evasion of Apoptosis: Both Aurora A and B can aid cancer cells in evading apoptosis, thereby promoting survival and proliferation.
