What are the Challenges in Targeting Aurora Kinases?
Despite the promising therapeutic potential, there are several challenges:
- Specificity: Achieving high specificity for Aurora kinases without affecting other kinases is challenging. - Resistance: Cancer cells may develop resistance to Aurora kinase inhibitors, necessitating combination therapies or the development of next-generation inhibitors. - Side Effects: Inhibitors may cause significant side effects due to their impact on normal cells undergoing division.
