Cancer cells can alter tissue mechanics in several ways. They can change the stiffness and elasticity of the extracellular matrix (ECM) by producing enzymes like matrix metalloproteinases (MMPs) that degrade ECM components. This degradation not only facilitates the invasion of cancer cells but also creates a microenvironment that supports cancer growth. Additionally, cancer cells can exert mechanical forces on surrounding tissues, disrupting normal cellular architecture and function.
