Cancer cells adopt various strategies to evade apoptosis via the extrinsic pathway, including:
- Downregulation or mutation of death receptors. - Upregulation of decoy receptors (DcR1 and DcR2), which bind ligands without transmitting apoptotic signals. - Expression of FLIP (FLICE-inhibitory protein), which inhibits caspase-8 activation. - Alteration in signaling intermediates or downstream effectors to block apoptotic signaling.
