What are the Challenges in Targeting the Extrinsic Pathway?
Challenges in targeting the extrinsic pathway for cancer treatment include:
- Tumor Heterogeneity: Variability in the expression of death receptors and their ligands among different tumors or within the same tumor. - Toxicity: Systemic activation of death receptors can lead to undesirable side effects, such as hepatotoxicity observed with TRAIL-based therapies. - Resistance Mechanisms: Cancer cells may develop resistance to therapies targeting the extrinsic pathway, necessitating the need for combination approaches.
