What are the Clinical Implications of PALB2 Mutations?
Knowing one's PALB2 mutation status can significantly influence clinical management. For instance, individuals with PALB2 mutations may benefit from increased surveillance, including more frequent mammograms and MRI scans. Prophylactic measures, such as preventive mastectomy or oophorectomy, may also be considered. Additionally, certain targeted therapies like PARP inhibitors have shown promise in treating cancers associated with PALB2 mutations.
