How do CDKs function in normal cell cycle regulation?
In normal cell cycle regulation, CDKs form complexes with specific cyclins at different cell cycle stages. For instance, CDK4 and CDK6 associate with cyclin D during the G1 phase to promote the transition to the S phase. CDK2 binds with cyclin E for the G1/S transition and with cyclin A for S phase progression. CDK1, along with cyclin B, facilitates the G2/M transition. By precisely controlling these checkpoints, CDKs ensure accurate DNA replication and cell division.
