How Do Genetic Mutations Influence Cancer Phenotype?
Genetic mutations play a critical role in determining the phenotype of cancer cells. Mutations in oncogenes and tumor suppressor genes can drive the uncontrolled proliferation and survival of cancer cells. For example, mutations in the TP53 gene, which encodes the p53 protein, can lead to loss of cell cycle control and resistance to apoptosis, contributing to a more aggressive cancer phenotype.
