In cancer, alterations in intermediate filament expression and organization are common. These changes can influence tumor cell behavior, including proliferation, invasion, and metastasis. For instance, the overexpression of vimentin is often associated with epithelial-to-mesenchymal transition (EMT), a process that enhances the migratory and invasive capabilities of cancer cells. Similarly, the deregulation of keratin expression is linked to tumor aggressiveness.
