How Do Microfilaments Influence Cancer Progression?
The actin cytoskeleton is involved in the formation of structures such as lamellipodia and filopodia, which aid in cancer cell movement. This cytoskeletal reorganization is regulated by various signaling pathways, including the Rho family of GTPases. Dysregulation of these pathways can lead to enhanced motility and invasiveness of cancer cells, thereby facilitating metastasis. Targeting the interactions between actin and cancer progression has emerged as a potential strategy for cancer therapy.
