What are the Risks Associated with CYP3A4 Inhibitors?
While CYP3A4 inhibitors can enhance the effectiveness of cancer drugs, they can also increase the risk of toxicity. Elevated drug levels can lead to severe side effects, such as myelosuppression, neurotoxicity, and gastrointestinal toxicity. Therefore, the use of CYP3A4 inhibitors requires careful monitoring and dose adjustment of the affected chemotherapeutic agents.
