Why are CYP3A4 Inhibitors Important in Cancer Treatment?
In cancer treatment, the metabolism of chemotherapeutic drugs is a critical factor in determining their efficacy and safety. Many anticancer drugs are metabolized by CYP3A4. By using CYP3A4 inhibitors, oncologists can manipulate drug levels to achieve optimal therapeutic outcomes. For example, some chemotherapeutic agents like paclitaxel and docetaxel are extensively metabolized by CYP3A4. Inhibiting CYP3A4 can increase the concentration of these drugs in the bloodstream, potentially improving their anti-cancer effects.
