How do Non-Neuronal Cells Contribute to the Tumor Microenvironment?
The tumor microenvironment (TME) is a complex network that includes cancer cells and non-neuronal cells. These non-neuronal cells can include:
1. Fibroblasts: Cancer-associated fibroblasts (CAFs) are known to produce extracellular matrix components and cytokines that facilitate tumor growth and metastasis. 2. Immune Cells: Tumor-associated macrophages (TAMs), T cells, and other immune cells can either inhibit or promote tumor growth depending on their state of activation. 3. Endothelial Cells: These cells are involved in the formation of new blood vessels (angiogenesis), providing nutrients and oxygen to the growing tumor.
