How Do Oncogenes and Tumor Suppressors Influence Metabolism?
Oncogenes and tumor suppressors play a significant role in metabolic reprogramming. For instance, the oncogene MYC upregulates glycolysis and glutaminolysis, while the tumor suppressor p53 has roles in maintaining oxidative phosphorylation and controlling reactive oxygen species (ROS). Mutations in these genes can drive the metabolic changes that support tumor growth and survival.